Empowering host immunity by kinase-targeting in LSC

An Epidemic Model Structured by Host Immunity

In this paper we introduce a physiologically structured SIR epidemic model where the individuals are distributed according to their immune status. An individual immune status is assumed to increase during the infectious period and remain unchanged after the recovery. Recovered individuals can become reinfected at a rate which is a decreasing function of their immune status. We find that the pos...

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen.

TGF-β activated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK families and include no direct effectors of biochemical processes. Here, we identify over 200 subst...

Effect of Host Src-kinase Inhibition on Replication of Coxsackievirus B3 in vitro

Surviving host innate immunity

The entry of metastatic cancer cells into the liver can trigger a rapid inflammatory response with increased local production of tumor necrosis factor α (TNFα). We investigated the molecular mechanisms that protect tumor cells from TNFα-induced apoptosis. A molecular crosstalk between the TNFα/TNFR/NFκB and IGF-IR/PI3-K/AKT pathways was identified that leads to autocrine IL-6/IL-6R/STAT3 signal...

Vip And Host Immunity

VIP AND HOST IMMUNITYbyXIAOYU JIANGDecember 2012Advisor: Dr. Linda D. HazlettMajor: Anatomy and Cell BiologyDegree: Doctor of PhilosophyThe purpose of the current dissertation was to examine how VIP regulateshost immunity and corneal healing, specifically, its control of growth factors andTLR expression in the P. aeruginosa infected cornea. Firstly, VIP t...